Esametone
Brand names,
Esametone
Analogs
Esametone
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Esametone
Chemical_Formula
C22H30O5
Esametone
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Esametone
fda sheet
Esametone
msds (material safety sheet)
Esametone
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Esametone
Molecular Weight
374.471 g/mol
Esametone
Melting Point
232.5 oC
Esametone
H2O Solubility
120 mg/L
Esametone
State
Solid
Esametone
LogP
2.134
Esametone
Dosage Forms
Tablets; Suspension
Esametone
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Esametone
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Esametone
Absorption
Oral bioavailability 80-99%
Esametone
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Esametone
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Esametone
Organisms Affected
Humans and other mammals