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Brand names,
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Analogs
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Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
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Chemical_Formula
C22H30O5
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RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
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Molecular Weight
374.471 g/mol
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Melting Point
232.5 oC
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H2O Solubility
120 mg/L
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State
Solid
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LogP
2.134
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Dosage Forms
Tablets; Suspension
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Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
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Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
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Absorption
Oral bioavailability 80-99%
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side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
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Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
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Organisms Affected
Humans and other mammals