Firmacort
Brand names,
Firmacort
Analogs
Firmacort
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Firmacort
Chemical_Formula
C22H30O5
Firmacort
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Firmacort
fda sheet
Firmacort
msds (material safety sheet)
Firmacort
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Firmacort
Molecular Weight
374.471 g/mol
Firmacort
Melting Point
232.5 oC
Firmacort
H2O Solubility
120 mg/L
Firmacort
State
Solid
Firmacort
LogP
2.134
Firmacort
Dosage Forms
Tablets; Suspension
Firmacort
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Firmacort
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Firmacort
Absorption
Oral bioavailability 80-99%
Firmacort
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Firmacort
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Firmacort
Organisms Affected
Humans and other mammals