Mesopren
Brand names,
Mesopren
Analogs
Mesopren
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Mesopren
Chemical_Formula
C22H30O5
Mesopren
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Mesopren
fda sheet
Mesopren
msds (material safety sheet)
Mesopren
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Mesopren
Molecular Weight
374.471 g/mol
Mesopren
Melting Point
232.5 oC
Mesopren
H2O Solubility
120 mg/L
Mesopren
State
Solid
Mesopren
LogP
2.134
Mesopren
Dosage Forms
Tablets; Suspension
Mesopren
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Mesopren
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Mesopren
Absorption
Oral bioavailability 80-99%
Mesopren
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Mesopren
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Mesopren
Organisms Affected
Humans and other mammals