Methyleneprednisolone
Brand names,
Methyleneprednisolone
Analogs
Methyleneprednisolone
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Methyleneprednisolone
Chemical_Formula
C22H30O5
Methyleneprednisolone
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Methyleneprednisolone
fda sheet
Methyleneprednisolone
msds (material safety sheet)
Methyleneprednisolone
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Methyleneprednisolone
Molecular Weight
374.471 g/mol
Methyleneprednisolone
Melting Point
232.5 oC
Methyleneprednisolone
H2O Solubility
120 mg/L
Methyleneprednisolone
State
Solid
Methyleneprednisolone
LogP
2.134
Methyleneprednisolone
Dosage Forms
Tablets; Suspension
Methyleneprednisolone
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Methyleneprednisolone
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Methyleneprednisolone
Absorption
Oral bioavailability 80-99%
Methyleneprednisolone
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Methyleneprednisolone
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Methyleneprednisolone
Organisms Affected
Humans and other mammals