Medesone
Brand names,
Medesone
Analogs
Medesone
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Medesone
Chemical_Formula
C22H30O5
Medesone
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Medesone
fda sheet
Medesone
msds (material safety sheet)
Medesone
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Medesone
Molecular Weight
374.471 g/mol
Medesone
Melting Point
232.5 oC
Medesone
H2O Solubility
120 mg/L
Medesone
State
Solid
Medesone
LogP
2.134
Medesone
Dosage Forms
Tablets; Suspension
Medesone
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Medesone
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Medesone
Absorption
Oral bioavailability 80-99%
Medesone
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Medesone
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Medesone
Organisms Affected
Humans and other mammals