Metysolon
Brand names,
Metysolon
Analogs
Metysolon
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Metysolon
Chemical_Formula
C22H30O5
Metysolon
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Metysolon
fda sheet
Metysolon
msds (material safety sheet)
Metysolon
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Metysolon
Molecular Weight
374.471 g/mol
Metysolon
Melting Point
232.5 oC
Metysolon
H2O Solubility
120 mg/L
Metysolon
State
Solid
Metysolon
LogP
2.134
Metysolon
Dosage Forms
Tablets; Suspension
Metysolon
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Metysolon
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Metysolon
Absorption
Oral bioavailability 80-99%
Metysolon
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Metysolon
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Metysolon
Organisms Affected
Humans and other mammals