Artisone-Wyeth
Brand names,
Artisone-Wyeth
Analogs
Artisone-Wyeth
Brand Names Mixture
- Depo-Medrol with Lidocaine (Lidocaine Hydrochloride + Methylprednisolone Acetate)
- Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur)
- Methylprednisolone Sodium Succinate for Injection (Methylprednisolone + Water)
- Neo-Medrol (Methylprednisolone Acetate + Neomycin Sulfate)
- Neo-Medrol Acne Lotion (Aluminum Chlorohydrate + Methylprednisolone Acetate + Neomycin Sulfate + Sulfur)
Artisone-Wyeth
Chemical_Formula
C22H30O5
Artisone-Wyeth
RX_link
http://www.rxlist.com/cgi/generic/methprd.htm
Artisone-Wyeth
fda sheet
Artisone-Wyeth
msds (material safety sheet)
Artisone-Wyeth
Synthesis Reference
Sebek, Spero, U.S. Pat. 2,897,218 (1959)
Artisone-Wyeth
Molecular Weight
374.471 g/mol
Artisone-Wyeth
Melting Point
232.5 oC
Artisone-Wyeth
H2O Solubility
120 mg/L
Artisone-Wyeth
State
Solid
Artisone-Wyeth
LogP
2.134
Artisone-Wyeth
Dosage Forms
Tablets; Suspension
Artisone-Wyeth
Indication
Adjunctive therapy for short-term administration in rheumatoid arthritis.
Artisone-Wyeth
Pharmacology
Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Artisone-Wyeth
Absorption
Oral bioavailability 80-99%
Artisone-Wyeth
side effects and Toxicity
LD50=2000 mg/kg (orally in rat)
Artisone-Wyeth
Patient Information
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or
measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.
Artisone-Wyeth
Organisms Affected
Humans and other mammals