beta-Thiovaline
Brand names,
beta-Thiovaline
Analogs
beta-Thiovaline
Brand Names Mixture
beta-Thiovaline
Chemical_Formula
C5H11NO2S
beta-Thiovaline
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
beta-Thiovaline
fda sheet
beta-Thiovaline
msds (material safety sheet)
beta-Thiovaline
Synthesis Reference
No information avaliable
beta-Thiovaline
Molecular Weight
149.212 g/mol
beta-Thiovaline
Melting Point
198.5 oC
beta-Thiovaline
H2O Solubility
1.11E+005 mg/L
beta-Thiovaline
State
Solid
beta-Thiovaline
LogP
-2.09
beta-Thiovaline
Dosage Forms
Capsule; Tablet
beta-Thiovaline
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
beta-Thiovaline
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
beta-Thiovaline
Absorption
rapidly but incompletely
beta-Thiovaline
side effects and Toxicity
No information avaliable
beta-Thiovaline
Patient Information
No information avaliable
beta-Thiovaline
Organisms Affected
Humans and other mammals