Mercaptovaline
Brand names,
Mercaptovaline
Analogs
Mercaptovaline
Brand Names Mixture
Mercaptovaline
Chemical_Formula
C5H11NO2S
Mercaptovaline
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Mercaptovaline
fda sheet
Mercaptovaline
msds (material safety sheet)
Mercaptovaline
Synthesis Reference
No information avaliable
Mercaptovaline
Molecular Weight
149.212 g/mol
Mercaptovaline
Melting Point
198.5 oC
Mercaptovaline
H2O Solubility
1.11E+005 mg/L
Mercaptovaline
State
Solid
Mercaptovaline
LogP
-2.09
Mercaptovaline
Dosage Forms
Capsule; Tablet
Mercaptovaline
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Mercaptovaline
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Mercaptovaline
Absorption
rapidly but incompletely
Mercaptovaline
side effects and Toxicity
No information avaliable
Mercaptovaline
Patient Information
No information avaliable
Mercaptovaline
Organisms Affected
Humans and other mammals