Pendramine
Brand names,
Pendramine
Analogs
Pendramine
Brand Names Mixture
Pendramine
Chemical_Formula
C5H11NO2S
Pendramine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Pendramine
fda sheet
Pendramine
msds (material safety sheet)
Pendramine
Synthesis Reference
No information avaliable
Pendramine
Molecular Weight
149.212 g/mol
Pendramine
Melting Point
198.5 oC
Pendramine
H2O Solubility
1.11E+005 mg/L
Pendramine
State
Solid
Pendramine
LogP
-2.09
Pendramine
Dosage Forms
Capsule; Tablet
Pendramine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Pendramine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Pendramine
Absorption
rapidly but incompletely
Pendramine
side effects and Toxicity
No information avaliable
Pendramine
Patient Information
No information avaliable
Pendramine
Organisms Affected
Humans and other mammals