L-Penicillamine
Brand names,
L-Penicillamine
Analogs
L-Penicillamine
Brand Names Mixture
L-Penicillamine
Chemical_Formula
C5H11NO2S
L-Penicillamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
L-Penicillamine
fda sheet
L-Penicillamine
msds (material safety sheet)
L-Penicillamine
Synthesis Reference
No information avaliable
L-Penicillamine
Molecular Weight
149.212 g/mol
L-Penicillamine
Melting Point
198.5 oC
L-Penicillamine
H2O Solubility
1.11E+005 mg/L
L-Penicillamine
State
Solid
L-Penicillamine
LogP
-2.09
L-Penicillamine
Dosage Forms
Capsule; Tablet
L-Penicillamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
L-Penicillamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
L-Penicillamine
Absorption
rapidly but incompletely
L-Penicillamine
side effects and Toxicity
No information avaliable
L-Penicillamine
Patient Information
No information avaliable
L-Penicillamine
Organisms Affected
Humans and other mammals