D-Penicilamine
Brand names,
D-Penicilamine
Analogs
D-Penicilamine
Brand Names Mixture
D-Penicilamine
Chemical_Formula
C5H11NO2S
D-Penicilamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
D-Penicilamine
fda sheet
D-Penicilamine
msds (material safety sheet)
D-Penicilamine
Synthesis Reference
No information avaliable
D-Penicilamine
Molecular Weight
149.212 g/mol
D-Penicilamine
Melting Point
198.5 oC
D-Penicilamine
H2O Solubility
1.11E+005 mg/L
D-Penicilamine
State
Solid
D-Penicilamine
LogP
-2.09
D-Penicilamine
Dosage Forms
Capsule; Tablet
D-Penicilamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
D-Penicilamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
D-Penicilamine
Absorption
rapidly but incompletely
D-Penicilamine
side effects and Toxicity
No information avaliable
D-Penicilamine
Patient Information
No information avaliable
D-Penicilamine
Organisms Affected
Humans and other mammals