Metalcaptase
Brand names,
Metalcaptase
Analogs
Metalcaptase
Brand Names Mixture
Metalcaptase
Chemical_Formula
C5H11NO2S
Metalcaptase
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Metalcaptase
fda sheet
Metalcaptase
msds (material safety sheet)
Metalcaptase
Synthesis Reference
No information avaliable
Metalcaptase
Molecular Weight
149.212 g/mol
Metalcaptase
Melting Point
198.5 oC
Metalcaptase
H2O Solubility
1.11E+005 mg/L
Metalcaptase
State
Solid
Metalcaptase
LogP
-2.09
Metalcaptase
Dosage Forms
Capsule; Tablet
Metalcaptase
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Metalcaptase
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Metalcaptase
Absorption
rapidly but incompletely
Metalcaptase
side effects and Toxicity
No information avaliable
Metalcaptase
Patient Information
No information avaliable
Metalcaptase
Organisms Affected
Humans and other mammals