Reduced penicillamine
Brand names,
Reduced penicillamine
Analogs
Reduced penicillamine
Brand Names Mixture
Reduced penicillamine
Chemical_Formula
C5H11NO2S
Reduced penicillamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Reduced penicillamine
fda sheet
Reduced penicillamine
msds (material safety sheet)
Reduced penicillamine
Synthesis Reference
No information avaliable
Reduced penicillamine
Molecular Weight
149.212 g/mol
Reduced penicillamine
Melting Point
198.5 oC
Reduced penicillamine
H2O Solubility
1.11E+005 mg/L
Reduced penicillamine
State
Solid
Reduced penicillamine
LogP
-2.09
Reduced penicillamine
Dosage Forms
Capsule; Tablet
Reduced penicillamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Reduced penicillamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Reduced penicillamine
Absorption
rapidly but incompletely
Reduced penicillamine
side effects and Toxicity
No information avaliable
Reduced penicillamine
Patient Information
No information avaliable
Reduced penicillamine
Organisms Affected
Humans and other mammals