Distamine
Brand names,
Distamine
Analogs
Distamine
Brand Names Mixture
Distamine
Chemical_Formula
C5H11NO2S
Distamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Distamine
fda sheet
Distamine
msds (material safety sheet)
Distamine
Synthesis Reference
No information avaliable
Distamine
Molecular Weight
149.212 g/mol
Distamine
Melting Point
198.5 oC
Distamine
H2O Solubility
1.11E+005 mg/L
Distamine
State
Solid
Distamine
LogP
-2.09
Distamine
Dosage Forms
Capsule; Tablet
Distamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Distamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Distamine
Absorption
rapidly but incompletely
Distamine
side effects and Toxicity
No information avaliable
Distamine
Patient Information
No information avaliable
Distamine
Organisms Affected
Humans and other mammals