Trolovol
Brand names,
Trolovol
Analogs
Trolovol
Brand Names Mixture
Trolovol
Chemical_Formula
C5H11NO2S
Trolovol
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Trolovol
fda sheet
Trolovol
msds (material safety sheet)
Trolovol
Synthesis Reference
No information avaliable
Trolovol
Molecular Weight
149.212 g/mol
Trolovol
Melting Point
198.5 oC
Trolovol
H2O Solubility
1.11E+005 mg/L
Trolovol
State
Solid
Trolovol
LogP
-2.09
Trolovol
Dosage Forms
Capsule; Tablet
Trolovol
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Trolovol
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Trolovol
Absorption
rapidly but incompletely
Trolovol
side effects and Toxicity
No information avaliable
Trolovol
Patient Information
No information avaliable
Trolovol
Organisms Affected
Humans and other mammals