D-Penicyllamine
Brand names,
D-Penicyllamine
Analogs
D-Penicyllamine
Brand Names Mixture
D-Penicyllamine
Chemical_Formula
C5H11NO2S
D-Penicyllamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
D-Penicyllamine
fda sheet
D-Penicyllamine
msds (material safety sheet)
D-Penicyllamine
Synthesis Reference
No information avaliable
D-Penicyllamine
Molecular Weight
149.212 g/mol
D-Penicyllamine
Melting Point
198.5 oC
D-Penicyllamine
H2O Solubility
1.11E+005 mg/L
D-Penicyllamine
State
Solid
D-Penicyllamine
LogP
-2.09
D-Penicyllamine
Dosage Forms
Capsule; Tablet
D-Penicyllamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
D-Penicyllamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
D-Penicyllamine
Absorption
rapidly but incompletely
D-Penicyllamine
side effects and Toxicity
No information avaliable
D-Penicyllamine
Patient Information
No information avaliable
D-Penicyllamine
Organisms Affected
Humans and other mammals