PCA
Brand names,
PCA
Analogs
PCA
Brand Names Mixture
PCA
Chemical_Formula
C5H11NO2S
PCA
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
PCA
fda sheet
PCA
msds (material safety sheet)
PCA
Synthesis Reference
No information avaliable
PCA
Molecular Weight
149.212 g/mol
PCA
Melting Point
198.5 oC
PCA
H2O Solubility
1.11E+005 mg/L
PCA
State
Solid
PCA
LogP
-2.09
PCA
Dosage Forms
Capsule; Tablet
PCA
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
PCA
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
PCA
Absorption
rapidly but incompletely
PCA
side effects and Toxicity
No information avaliable
PCA
Patient Information
No information avaliable
PCA
Organisms Affected
Humans and other mammals