Perdolat
Brand names,
Perdolat
Analogs
Perdolat
Brand Names Mixture
Perdolat
Chemical_Formula
C5H11NO2S
Perdolat
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Perdolat
fda sheet
Perdolat
msds (material safety sheet)
Perdolat
Synthesis Reference
No information avaliable
Perdolat
Molecular Weight
149.212 g/mol
Perdolat
Melting Point
198.5 oC
Perdolat
H2O Solubility
1.11E+005 mg/L
Perdolat
State
Solid
Perdolat
LogP
-2.09
Perdolat
Dosage Forms
Capsule; Tablet
Perdolat
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Perdolat
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Perdolat
Absorption
rapidly but incompletely
Perdolat
side effects and Toxicity
No information avaliable
Perdolat
Patient Information
No information avaliable
Perdolat
Organisms Affected
Humans and other mammals