Penicilllamine
Brand names,
Penicilllamine
Analogs
Penicilllamine
Brand Names Mixture
Penicilllamine
Chemical_Formula
C5H11NO2S
Penicilllamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Penicilllamine
fda sheet
Penicilllamine
msds (material safety sheet)
Penicilllamine
Synthesis Reference
No information avaliable
Penicilllamine
Molecular Weight
149.212 g/mol
Penicilllamine
Melting Point
198.5 oC
Penicilllamine
H2O Solubility
1.11E+005 mg/L
Penicilllamine
State
Solid
Penicilllamine
LogP
-2.09
Penicilllamine
Dosage Forms
Capsule; Tablet
Penicilllamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Penicilllamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Penicilllamine
Absorption
rapidly but incompletely
Penicilllamine
side effects and Toxicity
No information avaliable
Penicilllamine
Patient Information
No information avaliable
Penicilllamine
Organisms Affected
Humans and other mammals