Kuprenil
Brand names,
Kuprenil
Analogs
Kuprenil
Brand Names Mixture
Kuprenil
Chemical_Formula
C5H11NO2S
Kuprenil
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Kuprenil
fda sheet
Kuprenil
msds (material safety sheet)
Kuprenil
Synthesis Reference
No information avaliable
Kuprenil
Molecular Weight
149.212 g/mol
Kuprenil
Melting Point
198.5 oC
Kuprenil
H2O Solubility
1.11E+005 mg/L
Kuprenil
State
Solid
Kuprenil
LogP
-2.09
Kuprenil
Dosage Forms
Capsule; Tablet
Kuprenil
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Kuprenil
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Kuprenil
Absorption
rapidly but incompletely
Kuprenil
side effects and Toxicity
No information avaliable
Kuprenil
Patient Information
No information avaliable
Kuprenil
Organisms Affected
Humans and other mammals