Depamine
Brand names,
Depamine
Analogs
Depamine
Brand Names Mixture
Depamine
Chemical_Formula
C5H11NO2S
Depamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Depamine
fda sheet
Depamine
msds (material safety sheet)
Depamine
Synthesis Reference
No information avaliable
Depamine
Molecular Weight
149.212 g/mol
Depamine
Melting Point
198.5 oC
Depamine
H2O Solubility
1.11E+005 mg/L
Depamine
State
Solid
Depamine
LogP
-2.09
Depamine
Dosage Forms
Capsule; Tablet
Depamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Depamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Depamine
Absorption
rapidly but incompletely
Depamine
side effects and Toxicity
No information avaliable
Depamine
Patient Information
No information avaliable
Depamine
Organisms Affected
Humans and other mammals