HiFD`JxPBLbdTljjZDp@
Brand names,
HiFD`JxPBLbdTljjZDp@
Analogs
HiFD`JxPBLbdTljjZDp@
Brand Names Mixture
HiFD`JxPBLbdTljjZDp@
Chemical_Formula
C5H11NO2S
HiFD`JxPBLbdTljjZDp@
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
HiFD`JxPBLbdTljjZDp@
fda sheet
HiFD`JxPBLbdTljjZDp@
msds (material safety sheet)
HiFD`JxPBLbdTljjZDp@
Synthesis Reference
No information avaliable
HiFD`JxPBLbdTljjZDp@
Molecular Weight
149.212 g/mol
HiFD`JxPBLbdTljjZDp@
Melting Point
198.5 oC
HiFD`JxPBLbdTljjZDp@
H2O Solubility
1.11E+005 mg/L
HiFD`JxPBLbdTljjZDp@
State
Solid
HiFD`JxPBLbdTljjZDp@
LogP
-2.09
HiFD`JxPBLbdTljjZDp@
Dosage Forms
Capsule; Tablet
HiFD`JxPBLbdTljjZDp@
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
HiFD`JxPBLbdTljjZDp@
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
HiFD`JxPBLbdTljjZDp@
Absorption
rapidly but incompletely
HiFD`JxPBLbdTljjZDp@
side effects and Toxicity
No information avaliable
HiFD`JxPBLbdTljjZDp@
Patient Information
No information avaliable
HiFD`JxPBLbdTljjZDp@
Organisms Affected
Humans and other mammals