Cupripen
Brand names,
Cupripen
Analogs
Cupripen
Brand Names Mixture
Cupripen
Chemical_Formula
C5H11NO2S
Cupripen
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Cupripen
fda sheet
Cupripen
msds (material safety sheet)
Cupripen
Synthesis Reference
No information avaliable
Cupripen
Molecular Weight
149.212 g/mol
Cupripen
Melting Point
198.5 oC
Cupripen
H2O Solubility
1.11E+005 mg/L
Cupripen
State
Solid
Cupripen
LogP
-2.09
Cupripen
Dosage Forms
Capsule; Tablet
Cupripen
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Cupripen
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Cupripen
Absorption
rapidly but incompletely
Cupripen
side effects and Toxicity
No information avaliable
Cupripen
Patient Information
No information avaliable
Cupripen
Organisms Affected
Humans and other mammals