Penicillamin
Brand names,
Penicillamin
Analogs
Penicillamin
Brand Names Mixture
Penicillamin
Chemical_Formula
C5H11NO2S
Penicillamin
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Penicillamin
fda sheet
Penicillamin
msds (material safety sheet)
Penicillamin
Synthesis Reference
No information avaliable
Penicillamin
Molecular Weight
149.212 g/mol
Penicillamin
Melting Point
198.5 oC
Penicillamin
H2O Solubility
1.11E+005 mg/L
Penicillamin
State
Solid
Penicillamin
LogP
-2.09
Penicillamin
Dosage Forms
Capsule; Tablet
Penicillamin
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Penicillamin
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Penicillamin
Absorption
rapidly but incompletely
Penicillamin
side effects and Toxicity
No information avaliable
Penicillamin
Patient Information
No information avaliable
Penicillamin
Organisms Affected
Humans and other mammals