D-Mercaptovaline
Brand names,
D-Mercaptovaline
Analogs
D-Mercaptovaline
Brand Names Mixture
D-Mercaptovaline
Chemical_Formula
C5H11NO2S
D-Mercaptovaline
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
D-Mercaptovaline
fda sheet
D-Mercaptovaline
msds (material safety sheet)
D-Mercaptovaline
Synthesis Reference
No information avaliable
D-Mercaptovaline
Molecular Weight
149.212 g/mol
D-Mercaptovaline
Melting Point
198.5 oC
D-Mercaptovaline
H2O Solubility
1.11E+005 mg/L
D-Mercaptovaline
State
Solid
D-Mercaptovaline
LogP
-2.09
D-Mercaptovaline
Dosage Forms
Capsule; Tablet
D-Mercaptovaline
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
D-Mercaptovaline
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
D-Mercaptovaline
Absorption
rapidly but incompletely
D-Mercaptovaline
side effects and Toxicity
No information avaliable
D-Mercaptovaline
Patient Information
No information avaliable
D-Mercaptovaline
Organisms Affected
Humans and other mammals