D-Penamine
Brand names,
D-Penamine
Analogs
D-Penamine
Brand Names Mixture
D-Penamine
Chemical_Formula
C5H11NO2S
D-Penamine
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
D-Penamine
fda sheet
D-Penamine
msds (material safety sheet)
D-Penamine
Synthesis Reference
No information avaliable
D-Penamine
Molecular Weight
149.212 g/mol
D-Penamine
Melting Point
198.5 oC
D-Penamine
H2O Solubility
1.11E+005 mg/L
D-Penamine
State
Solid
D-Penamine
LogP
-2.09
D-Penamine
Dosage Forms
Capsule; Tablet
D-Penamine
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
D-Penamine
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
D-Penamine
Absorption
rapidly but incompletely
D-Penamine
side effects and Toxicity
No information avaliable
D-Penamine
Patient Information
No information avaliable
D-Penamine
Organisms Affected
Humans and other mammals