Sufirtan
Brand names,
Sufirtan
Analogs
Sufirtan
Brand Names Mixture
Sufirtan
Chemical_Formula
C5H11NO2S
Sufirtan
RX_link
http://www.rxlist.com/cgi/generic3/penicillamine.htm
Sufirtan
fda sheet
Sufirtan
msds (material safety sheet)
Sufirtan
Synthesis Reference
No information avaliable
Sufirtan
Molecular Weight
149.212 g/mol
Sufirtan
Melting Point
198.5 oC
Sufirtan
H2O Solubility
1.11E+005 mg/L
Sufirtan
State
Solid
Sufirtan
LogP
-2.09
Sufirtan
Dosage Forms
Capsule; Tablet
Sufirtan
Indication
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis
Sufirtan
Pharmacology
Penicillamine is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy. Penicillamine is used as a form of immunosuppression to treat rheumatoid arthritis. It works by reducing numbers of T-lymphocytes, inhibiting macrophage function, decreasing IL-1, decreasing rheumatoid factor, and preventing collagen from cross-linking. Its use in Wilson's disease, a rare genetic disorder of copper metabolism, relies on its binding to accumulated copper and elimination through urine.
Sufirtan
Absorption
rapidly but incompletely
Sufirtan
side effects and Toxicity
No information avaliable
Sufirtan
Patient Information
No information avaliable
Sufirtan
Organisms Affected
Humans and other mammals