Tetrahydrobiopterin en es it fr

Tetrahydrobiopterin Brand names, Tetrahydrobiopterin Analogs

Tetrahydrobiopterin Brand Names Mixture

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Tetrahydrobiopterin Chemical_Formula


Tetrahydrobiopterin RX_link

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Tetrahydrobiopterin fda sheet

Tetrahydrobiopterin msds (material safety sheet)

Tetrahydrobiopterin Synthesis Reference

No information avaliable

Tetrahydrobiopterin Molecular Weight

241.247 g/mol

Tetrahydrobiopterin Melting Point

250-255 oC (hydrochloride salt)

Tetrahydrobiopterin H2O Solubility

>20 mg/mL (dichloride salt)

Tetrahydrobiopterin State


Tetrahydrobiopterin LogP


Tetrahydrobiopterin Dosage Forms

No information avaliable

Tetrahydrobiopterin Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Tetrahydrobiopterin Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Tetrahydrobiopterin Absorption

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Tetrahydrobiopterin side effects and Toxicity

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Tetrahydrobiopterin Patient Information

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Tetrahydrobiopterin Organisms Affected

Humans and other mammals