Reno-dip
Brand names,
Reno-dip
Analogs
Reno-dip
Brand Names Mixture
Reno-dip
Chemical_Formula
C9H15N5O3
Reno-dip
RX_link
No information avaliable
Reno-dip
fda sheet
Reno-dip
msds (material safety sheet)
Reno-dip
Synthesis Reference
No information avaliable
Reno-dip
Molecular Weight
241.247 g/mol
Reno-dip
Melting Point
250-255 oC (hydrochloride salt)
Reno-dip
H2O Solubility
>20 mg/mL (dichloride salt)
Reno-dip
State
Solid
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LogP
-1.783
Reno-dip
Dosage Forms
No information avaliable
Reno-dip
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Reno-dip
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Reno-dip
Absorption
No information avaliable
Reno-dip
side effects and Toxicity
No information avaliable
Reno-dip
Patient Information
No information avaliable
Reno-dip
Organisms Affected
Humans and other mammals