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Triombrine Brand names, Triombrine Analogs

Triombrine Brand Names Mixture

  • No information avaliable

Triombrine Chemical_Formula


Triombrine RX_link

No information avaliable

Triombrine fda sheet

Triombrine msds (material safety sheet)

Triombrine Synthesis Reference

No information avaliable

Triombrine Molecular Weight

241.247 g/mol

Triombrine Melting Point

250-255 oC (hydrochloride salt)

Triombrine H2O Solubility

>20 mg/mL (dichloride salt)

Triombrine State


Triombrine LogP


Triombrine Dosage Forms

No information avaliable

Triombrine Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Triombrine Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Triombrine Absorption

No information avaliable

Triombrine side effects and Toxicity

No information avaliable

Triombrine Patient Information

No information avaliable

Triombrine Organisms Affected

Humans and other mammals