Diatrizoesaure [German]

• Dietary supplement
• Cofactor

• Acide amidotrizoique
• Acidum amidotrizoicum
• Acidum diacetylaminotrijodbenzoicum
• AmiDOTrizoic acid
• Amidotrizoate
• Angiovist 282
• Cardiografin
• Conray 35
• DIAT [German]
• Diat
• Diatriazoate
• Diatrizoate sodium
• Diatrizoate sodium salt
• Diatrizoesaeure
• Diatrizoesaure
• Diatrizoesaure [German]
• Diatrizoic acid
• Diatrizoic acid [USAN:BAN]
• Diatrizoic acid sodium salt
• Gastrografin
• Hypaque
• Hypaque 50
• Hypaque sodium
• Iothalamate
• Meglumine diatrizoate
• Methalamic acid
• Odiston
• Reno-dip
• Renografin 76
• Sodium amidotrizoate
• Sodium diatrizoate
• Triombrin
• Triombrin [Russian]
• Triombrine
• Urografic acid, sodium salt
• Urografin acid
• Urogranoic acid
• Urotrast
• Urovison
• Urovist Cysto
• Urovist Cysto Pediatric
• Urovist Meglumine Diu/ct
• Urovist Sodium 300
• Vascoray

• No information avaliable

C₉H₁₅N₅O₃

No information avaliable

No information avaliable

241.247 g/mol

250-255 ^oC (hydrochloride salt)

>20 mg/mL (dichloride salt)

Solid

-1.783

No information avaliable

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

No information avaliable

No information avaliable

No information avaliable

Humans and other mammals