Renografin 76
Brand names,
Renografin 76
Analogs
Renografin 76
Brand Names Mixture
Renografin 76
Chemical_Formula
C9H15N5O3
Renografin 76
RX_link
No information avaliable
Renografin 76
fda sheet
Renografin 76
msds (material safety sheet)
Renografin 76
Synthesis Reference
No information avaliable
Renografin 76
Molecular Weight
241.247 g/mol
Renografin 76
Melting Point
250-255 oC (hydrochloride salt)
Renografin 76
H2O Solubility
>20 mg/mL (dichloride salt)
Renografin 76
State
Solid
Renografin 76
LogP
-1.783
Renografin 76
Dosage Forms
No information avaliable
Renografin 76
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Renografin 76
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Renografin 76
Absorption
No information avaliable
Renografin 76
side effects and Toxicity
No information avaliable
Renografin 76
Patient Information
No information avaliable
Renografin 76
Organisms Affected
Humans and other mammals