Hypaque 50
Brand names,
Hypaque 50
Analogs
Hypaque 50
Brand Names Mixture
Hypaque 50
Chemical_Formula
C9H15N5O3
Hypaque 50
RX_link
No information avaliable
Hypaque 50
fda sheet
Hypaque 50
msds (material safety sheet)
Hypaque 50
Synthesis Reference
No information avaliable
Hypaque 50
Molecular Weight
241.247 g/mol
Hypaque 50
Melting Point
250-255 oC (hydrochloride salt)
Hypaque 50
H2O Solubility
>20 mg/mL (dichloride salt)
Hypaque 50
State
Solid
Hypaque 50
LogP
-1.783
Hypaque 50
Dosage Forms
No information avaliable
Hypaque 50
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Hypaque 50
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Hypaque 50
Absorption
No information avaliable
Hypaque 50
side effects and Toxicity
No information avaliable
Hypaque 50
Patient Information
No information avaliable
Hypaque 50
Organisms Affected
Humans and other mammals