Conray 35
Brand names,
Conray 35
Analogs
Conray 35
Brand Names Mixture
Conray 35
Chemical_Formula
C9H15N5O3
Conray 35
RX_link
No information avaliable
Conray 35
fda sheet
Conray 35
msds (material safety sheet)
Conray 35
Synthesis Reference
No information avaliable
Conray 35
Molecular Weight
241.247 g/mol
Conray 35
Melting Point
250-255 oC (hydrochloride salt)
Conray 35
H2O Solubility
>20 mg/mL (dichloride salt)
Conray 35
State
Solid
Conray 35
LogP
-1.783
Conray 35
Dosage Forms
No information avaliable
Conray 35
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Conray 35
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Conray 35
Absorption
No information avaliable
Conray 35
side effects and Toxicity
No information avaliable
Conray 35
Patient Information
No information avaliable
Conray 35
Organisms Affected
Humans and other mammals