Hypaque sodium
Brand names,
Hypaque sodium
Analogs
Hypaque sodium
Brand Names Mixture
Hypaque sodium
Chemical_Formula
C9H15N5O3
Hypaque sodium
RX_link
No information avaliable
Hypaque sodium
fda sheet
Hypaque sodium
msds (material safety sheet)
Hypaque sodium
Synthesis Reference
No information avaliable
Hypaque sodium
Molecular Weight
241.247 g/mol
Hypaque sodium
Melting Point
250-255 oC (hydrochloride salt)
Hypaque sodium
H2O Solubility
>20 mg/mL (dichloride salt)
Hypaque sodium
State
Solid
Hypaque sodium
LogP
-1.783
Hypaque sodium
Dosage Forms
No information avaliable
Hypaque sodium
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Hypaque sodium
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Hypaque sodium
Absorption
No information avaliable
Hypaque sodium
side effects and Toxicity
No information avaliable
Hypaque sodium
Patient Information
No information avaliable
Hypaque sodium
Organisms Affected
Humans and other mammals