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DIAT [German] Brand names, DIAT [German] Analogs

DIAT [German] Brand Names Mixture

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DIAT [German] Chemical_Formula


DIAT [German] RX_link

No information avaliable

DIAT [German] fda sheet

DIAT [German] msds (material safety sheet)

DIAT [German] Synthesis Reference

No information avaliable

DIAT [German] Molecular Weight

241.247 g/mol

DIAT [German] Melting Point

250-255 oC (hydrochloride salt)

DIAT [German] H2O Solubility

>20 mg/mL (dichloride salt)

DIAT [German] State


DIAT [German] LogP


DIAT [German] Dosage Forms

No information avaliable

DIAT [German] Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

DIAT [German] Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

DIAT [German] Absorption

No information avaliable

DIAT [German] side effects and Toxicity

No information avaliable

DIAT [German] Patient Information

No information avaliable

DIAT [German] Organisms Affected

Humans and other mammals