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Amidotrizoate Brand names, Amidotrizoate Analogs

Amidotrizoate Brand Names Mixture

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Amidotrizoate Chemical_Formula


Amidotrizoate RX_link

No information avaliable

Amidotrizoate fda sheet

Amidotrizoate msds (material safety sheet)

Amidotrizoate Synthesis Reference

No information avaliable

Amidotrizoate Molecular Weight

241.247 g/mol

Amidotrizoate Melting Point

250-255 oC (hydrochloride salt)

Amidotrizoate H2O Solubility

>20 mg/mL (dichloride salt)

Amidotrizoate State


Amidotrizoate LogP


Amidotrizoate Dosage Forms

No information avaliable

Amidotrizoate Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Amidotrizoate Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Amidotrizoate Absorption

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Amidotrizoate side effects and Toxicity

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Amidotrizoate Patient Information

No information avaliable

Amidotrizoate Organisms Affected

Humans and other mammals