Diatrizoate sodium salt
Brand names,
Diatrizoate sodium salt
Analogs
Diatrizoate sodium salt
Brand Names Mixture
Diatrizoate sodium salt
Chemical_Formula
C9H15N5O3
Diatrizoate sodium salt
RX_link
No information avaliable
Diatrizoate sodium salt
fda sheet
Diatrizoate sodium salt
msds (material safety sheet)
Diatrizoate sodium salt
Synthesis Reference
No information avaliable
Diatrizoate sodium salt
Molecular Weight
241.247 g/mol
Diatrizoate sodium salt
Melting Point
250-255 oC (hydrochloride salt)
Diatrizoate sodium salt
H2O Solubility
>20 mg/mL (dichloride salt)
Diatrizoate sodium salt
State
Solid
Diatrizoate sodium salt
LogP
-1.783
Diatrizoate sodium salt
Dosage Forms
No information avaliable
Diatrizoate sodium salt
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Diatrizoate sodium salt
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Diatrizoate sodium salt
Absorption
No information avaliable
Diatrizoate sodium salt
side effects and Toxicity
No information avaliable
Diatrizoate sodium salt
Patient Information
No information avaliable
Diatrizoate sodium salt
Organisms Affected
Humans and other mammals