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Iothalamate Brand names, Iothalamate Analogs

Iothalamate Brand Names Mixture

  • No information avaliable

Iothalamate Chemical_Formula


Iothalamate RX_link

No information avaliable

Iothalamate fda sheet

Iothalamate msds (material safety sheet)

Iothalamate Synthesis Reference

No information avaliable

Iothalamate Molecular Weight

241.247 g/mol

Iothalamate Melting Point

250-255 oC (hydrochloride salt)

Iothalamate H2O Solubility

>20 mg/mL (dichloride salt)

Iothalamate State


Iothalamate LogP


Iothalamate Dosage Forms

No information avaliable

Iothalamate Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Iothalamate Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Iothalamate Absorption

No information avaliable

Iothalamate side effects and Toxicity

No information avaliable

Iothalamate Patient Information

No information avaliable

Iothalamate Organisms Affected

Humans and other mammals