Methalamic acid en es it fr

Methalamic acid Brand names, Methalamic acid Analogs

Methalamic acid Brand Names Mixture

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Methalamic acid Chemical_Formula


Methalamic acid RX_link

No information avaliable

Methalamic acid fda sheet

Methalamic acid msds (material safety sheet)

Methalamic acid Synthesis Reference

No information avaliable

Methalamic acid Molecular Weight

241.247 g/mol

Methalamic acid Melting Point

250-255 oC (hydrochloride salt)

Methalamic acid H2O Solubility

>20 mg/mL (dichloride salt)

Methalamic acid State


Methalamic acid LogP


Methalamic acid Dosage Forms

No information avaliable

Methalamic acid Indication

For the treatment of tetrahydrobiopterin (BH4) deficiency.

Methalamic acid Pharmacology

Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.

Methalamic acid Absorption

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Methalamic acid side effects and Toxicity

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Methalamic acid Patient Information

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Methalamic acid Organisms Affected

Humans and other mammals