Vascoray
Brand names,
Vascoray
Analogs
Vascoray
Brand Names Mixture
Vascoray
Chemical_Formula
C9H15N5O3
Vascoray
RX_link
No information avaliable
Vascoray
fda sheet
Vascoray
msds (material safety sheet)
Vascoray
Synthesis Reference
No information avaliable
Vascoray
Molecular Weight
241.247 g/mol
Vascoray
Melting Point
250-255 oC (hydrochloride salt)
Vascoray
H2O Solubility
>20 mg/mL (dichloride salt)
Vascoray
State
Solid
Vascoray
LogP
-1.783
Vascoray
Dosage Forms
No information avaliable
Vascoray
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Vascoray
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Vascoray
Absorption
No information avaliable
Vascoray
side effects and Toxicity
No information avaliable
Vascoray
Patient Information
No information avaliable
Vascoray
Organisms Affected
Humans and other mammals