Urovist Sodium 300
Brand names,
Urovist Sodium 300
Analogs
Urovist Sodium 300
Brand Names Mixture
Urovist Sodium 300
Chemical_Formula
C9H15N5O3
Urovist Sodium 300
RX_link
No information avaliable
Urovist Sodium 300
fda sheet
Urovist Sodium 300
msds (material safety sheet)
Urovist Sodium 300
Synthesis Reference
No information avaliable
Urovist Sodium 300
Molecular Weight
241.247 g/mol
Urovist Sodium 300
Melting Point
250-255 oC (hydrochloride salt)
Urovist Sodium 300
H2O Solubility
>20 mg/mL (dichloride salt)
Urovist Sodium 300
State
Solid
Urovist Sodium 300
LogP
-1.783
Urovist Sodium 300
Dosage Forms
No information avaliable
Urovist Sodium 300
Indication
For the treatment of tetrahydrobiopterin (BH4) deficiency.
Urovist Sodium 300
Pharmacology
Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine, to other essential molecules in the body including neurotransmitters. Tetrahydrobiopterin deficiency can be caused by mutations in GTP cyclohydrolase 1 (GCH1), 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), 6-pyruvoyltetrahydropterin synthase (PTS), and quinoid dihydropteridine reductase (QDPR) genes. These genes make the enzymes that are critical for producing and recycling tetrahydrobiopterin. If one of the enzymes fails to function correctly because of a gene mutation, little or no tetrahydrobiopterin is produced. As a result, phenylalanine from the diet builds up in the bloodstream and other tissues and can damage nerve cells in the brain. High levels of phenylalanine can result in signs and symptoms ranging from temporary low muscle tone to mental retardation, movement disorders, difficulty swallowing, seizures, behavioral problems, progressive problems with development, and an inability to control body temperature.
Urovist Sodium 300
Absorption
No information avaliable
Urovist Sodium 300
side effects and Toxicity
No information avaliable
Urovist Sodium 300
Patient Information
No information avaliable
Urovist Sodium 300
Organisms Affected
Humans and other mammals