Rifaximin
Brand names,
Rifaximin
Analogs
Rifaximin
Brand Names Mixture
Rifaximin
Chemical_Formula
C43H51N3O11
Rifaximin
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Rifaximin
fda sheet
Rifaximin
msds (material safety sheet)
Rifaximin
Synthesis Reference
No information avaliable
Rifaximin
Molecular Weight
785.879 g/mol
Rifaximin
Melting Point
No information avaliable
Rifaximin
H2O Solubility
No information avaliable
Rifaximin
State
No information avaliable
Rifaximin
LogP
4.161
Rifaximin
Dosage Forms
No information avaliable
Rifaximin
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Rifaximin
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Rifaximin
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Rifaximin
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Rifaximin
Patient Information
No information avaliable
Rifaximin
Organisms Affected
Enteric bacteria and eubacteria