Zinastat
Brand names,
Zinastat
Analogs
Zinastat
Brand Names Mixture
Zinastat
Chemical_Formula
C43H51N3O11
Zinastat
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Zinastat
fda sheet
Zinastat
msds (material safety sheet)
Zinastat
Synthesis Reference
No information avaliable
Zinastat
Molecular Weight
785.879 g/mol
Zinastat
Melting Point
No information avaliable
Zinastat
H2O Solubility
No information avaliable
Zinastat
State
No information avaliable
Zinastat
LogP
4.161
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Dosage Forms
No information avaliable
Zinastat
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Zinastat
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Zinastat
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Zinastat
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Zinastat
Patient Information
No information avaliable
Zinastat
Organisms Affected
Enteric bacteria and eubacteria