Zinamide
Brand names,
Zinamide
Analogs
Zinamide
Brand Names Mixture
Zinamide
Chemical_Formula
C43H51N3O11
Zinamide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Zinamide
fda sheet
Zinamide
msds (material safety sheet)
Zinamide
Synthesis Reference
No information avaliable
Zinamide
Molecular Weight
785.879 g/mol
Zinamide
Melting Point
No information avaliable
Zinamide
H2O Solubility
No information avaliable
Zinamide
State
No information avaliable
Zinamide
LogP
4.161
Zinamide
Dosage Forms
No information avaliable
Zinamide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Zinamide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Zinamide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Zinamide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Zinamide
Patient Information
No information avaliable
Zinamide
Organisms Affected
Enteric bacteria and eubacteria