Pezetamid
Brand names,
Pezetamid
Analogs
Pezetamid
Brand Names Mixture
Pezetamid
Chemical_Formula
C43H51N3O11
Pezetamid
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pezetamid
fda sheet
Pezetamid
msds (material safety sheet)
Pezetamid
Synthesis Reference
No information avaliable
Pezetamid
Molecular Weight
785.879 g/mol
Pezetamid
Melting Point
No information avaliable
Pezetamid
H2O Solubility
No information avaliable
Pezetamid
State
No information avaliable
Pezetamid
LogP
4.161
Pezetamid
Dosage Forms
No information avaliable
Pezetamid
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pezetamid
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pezetamid
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pezetamid
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pezetamid
Patient Information
No information avaliable
Pezetamid
Organisms Affected
Enteric bacteria and eubacteria