Pyrazinecarboxamide
Brand names,
Pyrazinecarboxamide
Analogs
Pyrazinecarboxamide
Brand Names Mixture
Pyrazinecarboxamide
Chemical_Formula
C43H51N3O11
Pyrazinecarboxamide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pyrazinecarboxamide
fda sheet
Pyrazinecarboxamide
msds (material safety sheet)
Pyrazinecarboxamide
Synthesis Reference
No information avaliable
Pyrazinecarboxamide
Molecular Weight
785.879 g/mol
Pyrazinecarboxamide
Melting Point
No information avaliable
Pyrazinecarboxamide
H2O Solubility
No information avaliable
Pyrazinecarboxamide
State
No information avaliable
Pyrazinecarboxamide
LogP
4.161
Pyrazinecarboxamide
Dosage Forms
No information avaliable
Pyrazinecarboxamide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pyrazinecarboxamide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pyrazinecarboxamide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pyrazinecarboxamide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pyrazinecarboxamide
Patient Information
No information avaliable
Pyrazinecarboxamide
Organisms Affected
Enteric bacteria and eubacteria