Pyrazineamide
Brand names,
Pyrazineamide
Analogs
Pyrazineamide
Brand Names Mixture
Pyrazineamide
Chemical_Formula
C43H51N3O11
Pyrazineamide
RX_link
http://www.rxlist.com/cgi/generic/xifaxan.htm
Pyrazineamide
fda sheet
Pyrazineamide
msds (material safety sheet)
Pyrazineamide
Synthesis Reference
No information avaliable
Pyrazineamide
Molecular Weight
785.879 g/mol
Pyrazineamide
Melting Point
No information avaliable
Pyrazineamide
H2O Solubility
No information avaliable
Pyrazineamide
State
No information avaliable
Pyrazineamide
LogP
4.161
Pyrazineamide
Dosage Forms
No information avaliable
Pyrazineamide
Indication
For the treatment of patients (>=12 years of age) with travelers' diarrhea caused by noninvasive strains of Escherichia coli.
Pyrazineamide
Pharmacology
Rifaximin is a structural analog of rifampin and non-systemic, gastrointestinal site-specific antibiotic. Rifaximin acts by inhibiting bacterial ribonucleic acid (RNA) synthesis. While an increase in pulmonary hydrogen excretion is evident in diverticular disease, the therapeutic effect of rifaximin does not appear to be due to a persistent correction of this alteration and the drug appears to cause no significant imbalance in the intestinal ecosystem.
Pyrazineamide
Absorption
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Pyrazineamide
side effects and Toxicity
LD50 > 2 g/kg (orally, in rats)
Pyrazineamide
Patient Information
No information avaliable
Pyrazineamide
Organisms Affected
Enteric bacteria and eubacteria